The skin is the largest organ in the body and the first to show the physical signs of aging. The appearance of fine lines, wrinkles, and the loss of elasticity and plumpness often lead people to seek out treatments to slow the external signs of aging. At ZenVita MedSpa, we believe it is essential to look beyond the surface and address the root causes of skin aging at the cellular level. Recent scientific evidence shows that cellular aging can be slowed using NAD+ supplements, benefiting not only the skin but the entire body.
CELLULAR DYSFUNCTION CAUSES SKIN AGING
Skin aging occurs due to both external and internal damage. External damage results from UV exposure, smoking, and pollution, while internal damage occurs as a result of the cellular aging process. While many topicals and treatments focus on reversing external signs of aging—such as fine lines, wrinkles, and loss of skin elasticity—it is crucial to also address the internal damage that impairs skin cell function.
At ZenVita MedSpa, we recognize that the cells in your skin experience cellular aging in the same way as the rest of your body. As cells lose their ability to repair and regenerate, damage accumulates, which prevents normal cellular function and leads to visible signs of skin aging.
The key cellular changes that cause aging are referred to as the “Hallmarks of Aging.” These include:
Loss of DNA repair: Leads to UV-induced photoaging.
Mitochondrial dysfunction: Reduces cellular energy production, necessary for skin cell turnover. This also increases free radical production, which damages cells.
Impaired protein folding and glycation: Causes an accumulation of damaged and dysfunctional proteins, such as stiffened collagen proteins, reducing skin flexibility.
Fibroblast damage: Collagen- and elastin-producing cells become damaged and senescent, reducing their ability to produce collagen.
Increased inflammation: Breaks down collagen and the scaffolding between skin cells, causing skin thinning.
· Figure 1 – The Hallmarks of Aging are the cellular changes that cause the physical signs of skin aging. The Hallmarks of Aging can be reversed by restoring cellular NAD+ levels.
NAD+ SUPPORTS SKIN HEALTH
Studies demonstrate that targeting the Hallmarks of Aging can slow and even reverse the cellular aging process. NAD+ is one of the few molecules known to positively impact all these hallmarks. In the context of skin health, NAD+ works to:
Activate cellular repair and maintenance pathways, such as DNA repair and antioxidant pathways.
Trigger healthy aging proteins, called sirtuins, which protect mitochondria by repairing them, triggering new mitochondria production, and recycling damaged ones.
Facilitate cellular energy production, which is critical for skin cell turnover.
Help reduce glycation and regulate protein folding and recycling to ensure damaged proteins are removed or repaired.
Reduce the number of senescent cells and prevent cells from becoming senescent.
Lower chronic inflammation in the skin.
In clinical trials, Nuchido TIME+ has been shown to significantly increase NAD+ levels and sirtuin activity, reduce inflammation, and decrease glycation. Improved skin health is one of the most reported benefits by users of Nuchido TIME+.
NAD+ CAN ENHANCE COLLAGEN SUPPLEMENTS
While many people use collagen supplements or topicals to boost collagen in the skin, these approaches do not address the root cause of the problem. Collagen levels decline as fibroblasts—the cells that produce collagen—become damaged and dysfunctional.
Figure 2 – How aging impacts the function of fibroblasts reducing their ability to produce vital proteins such as collagen and elastin.
At ZenVita MedSpa, we emphasize that the loss of NAD+ in these fibroblasts leads to reduced energy production and cellular repair. This allows damage to accumulate, decreasing their ability to produce collagen and elastin. It also increases inflammation in the skin, further compromising its structure and function. This cellular damage manifests as fine lines, wrinkles, loss of elasticity, and slower wound healing.
Figure 3 – How NAD+ restoration with Nuchido TIME+ works to restore the cellular health of fibroblasts, compared to the activity of collagen supplements.
By restoring NAD+ levels with Nuchido TIME+, you repair damaged fibroblasts, enabling them to produce more collagen and elastin. This approach goes beyond what collagen supplements can achieve, offering synergistic benefits when both are used together.
TAKE A CELLULAR APPROACH TO SKINCARE AT ZENVITA MEDSPA
By addressing both the internal and external signs of aging, NAD+ restoration with Nuchido TIME+ offers a powerful tool for cellular rejuvenation. Combining Nuchido TIME+ with other treatments, such as RF microneedling, laser therapies, and medical-grade skin care regimens, can significantly enhance results.
If you are interested in purchasing Nuchido TIME+ or learning more about how NAD+ can transform your skin, contact us at 720-224-8024 or email us at zenvitamedspa@gmail.com.
See more about the clinical trials with this video overview
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